GDS first reported on the variations in routes of administration of MDMA more than 10 years ago (when it was simply the Mixmag Drugs Survey). At the time, we wrote something about the rectal use of MDMA (E-by-bum) because it sounded a bit funny. A few years ago, GDS followed that up with a more serious piece about the phenomena of people using drugs rectally, the science behind it (pardon the pun) and how rectal use of drugs may convey certain benefits, though it requires a bit of planning, patience, practice and equipment.
GDS2017 took a more in depth look at the different way people use MDMA pills and powders around the world and that what I want to talk about here. Route of use is very important when thinking about drug effects (both pleasure and risk) and is probably overlooked compared to dose and drug purity. While the route you choose will be influenced by the form of drug you have at hand (pills or powder), 50% of our sample reported having used both pills and powder in the last 12 months (40% just powder and 10% just pills). Overall 90% of users take their MDMA orally (they swallow), while most of the remainder snort it
This illicit drug exerts its primary effects in the brain on neurons that use the chemicals serotonin, dopamine and norepinephrine to communicate with other neurons. Serotonin is most likely responsible for the feelings of empathy, elevated mood, and emotional closeness experienced with this drug. Overall, these neurotransmitter systems play an important role in regulating: Mdma 300 mg pills is most often available in tablet or capsule form and is usually ingested orally. Ecstasy traffickers consistently use brand names and logos as marketing tools and to distinguish their product from that of competitors. The logos may be produced to coincide with holidays or special events. Among the more popular logos are butterflies, lightning bolts, and four-leaf clovers. It is also available as a powder and is sometimes snorted, taken as a liquid, and it is occasionally smoked but rarely injected.